Abstract This study aimed to evaluate the effects of chronic use of fluoxetine on the amount of orthodontic tooth movement and tissue changes in rats. A total of 192 Wistar rats were divided into 4 groups: S, 0.9% saline solution; F, 20 mg/kg of fluoxetine; SM, 0.9% saline solution with orthodontic movement; and FM, 20 mg/kg of fluoxetine with orthodontic movement. After 30 days of daily saline or fluoxetine administration, an orthodontic device (25cN) was used to mesially displace the first molar in animals of the groups SM and FM. The animals were euthanized 2, 7, 14, and 28 days after placement of the orthodontic appliances and animals of groups S and F were euthanized at the same time. The assessment of tooth movement was made in gypsum castings, the collagen neoformation was assessed by polarization microscopy, the number of osteoclasts and root resorption were evaluated using tartrate-resistant acid phosphatase, and presence of hyalinized areas was assessed by hematoxylin-eosin staining. Fluoxetine did not affect the amount of tooth displacement, percentage of collagen, number of osteoclasts, and presence of hyalinized areas (P>0.05). There was a higher frequency of root resorption areas in the FM group than in the SM group only on the second day (P<0.05). The findings of this study show that chronic use of 20 mg/kg fluoxetine does not affect the amount of tooth movement, collagen neoformation, number of osteoclasts, or hyalinized areas and does not affect root resorption until the last day of orthodontic movement.

Abstract Factor X deficiency ranks among the rarest coagulopathies and has a variable presentation spectrum. We intend to present a proposal for anesthesia protocol for individuals with the coagulopathy. The excision of an ovarian neoplasm was proposed for a 26-year-old, female, ASA II patient, with congenital Factor X deficiency. Physical examination and lab tests were normal, except for Prothrombin Time (PT) 22.1s (VR: 8-14s), International Normalized Ratio (INR) 1.99 (VR: 0.8-1.2) and Activated Partial Thromboplastin Time (aPTT) 41.4s (VR: 25-37s). We concluded that a history of bleeding should always be investigated, along with a pre-anesthetic coagulation study.

Resumo O conceito de vulnerabilidade considera diferentes fatores que concorrem para a exposição de indivíduos e grupos a processos de adoecimento. Neste estudo, o referido conceito foi utilizado com o objetivo de avaliar a situação da saúde de 139 mulheres residentes em oito comunidades quilombolas, localizadas em uma área de exploração mineral, nas margens do Rio Trombetas, em Oriximiná (PA). O estudo serviu-se de entrevistas individuais semiestruturadas para coleta de dados, os quais foram submetidos a uma abordagem quantitativa e analisados por meio de estatística descritiva. Embora as comunidades quilombolas sejam historicamente vulneráveis, os dados evidenciaram que as mulheres são ainda mais fragilizadas por fatores individuais, sociais e programáticos que se revelam nas dificuldades de acesso à educação, à informação, ao trabalho, à renda e à saúde. Elas necessitam, portanto, de políticas públicas especialmente adequadas à sua condição de gênero e ao seu perfil sociocultural.

Abstract Vulnerability encompass different factors that contribute to exposing individuals and groups to the illness processes. In this study, this concept was used to assess the health situation of 139 women living in eight quilombola communities located in a mining area, on the banks of the Trombetas River, in Oriximiná, Pará, Brazil. Data were collected by semi-structured individual interviews, which underwent quantitative analysis and descriptive statistics. Although quilombola communities are historically vulnerable, women are further weakened by individual, social, and programmatic factors, revealed in the poor access to education, information, work, income and health. Hence, public policies specifically suited to their gender and socio-cultural profile are needed.

Resumo O conceito de vulnerabilidade considera diferentes fatores que concorrem para a exposição de indivíduos e grupos a processos de adoecimento. Neste estudo, o referido conceito foi utilizado com o objetivo de avaliar a situação da saúde de 139 mulheres residentes em oito comunidades quilombolas, localizadas em uma área de exploração mineral, nas margens do Rio Trombetas, em Oriximiná (PA). O estudo serviu-se de entrevistas individuais semiestruturadas para coleta de dados, os quais foram submetidos a uma abordagem quantitativa e analisados por meio de estatística descritiva. Embora as comunidades quilombolas sejam historicamente vulneráveis, os dados evidenciaram que as mulheres são ainda mais fragilizadas por fatores individuais, sociais e programáticos que se revelam nas dificuldades de acesso à educação, à informação, ao trabalho, à renda e à saúde. Elas necessitam, portanto, de políticas públicas especialmente adequadas à sua condição de gênero e ao seu perfil sociocultural.

Abstract Vulnerability encompass different factors that contribute to exposing individuals and groups to the illness processes. In this study, this concept was used to assess the health situation of 139 women living in eight quilombola communities located in a mining area, on the banks of the Trombetas River, in Oriximiná, Pará, Brazil. Data were collected by semi-structured individual interviews, which underwent quantitative analysis and descriptive statistics. Although quilombola communities are historically vulnerable, women are further weakened by individual, social, and programmatic factors, revealed in the poor access to education, information, work, income and health. Hence, public policies specifically suited to their gender and socio-cultural profile are needed.

Abstract Background The early detection of vascular damage in subclinical stages of hypertensive disease may be the key point in the prevention of cardiovascular outcomes. Objectives to correlate parameters of structural vascular damage (measurement of the carotid intima-media thickness) with parameters of functional vascular damage (central hemodynamic measurements) in pre-hypertensive and hypertensive patients taking up to two classes of anti-hypertensive drugs. Methods This was a cross-sectional descriptive study conducted with a convenience sample of patients attending the Liga de Hipertensão Arterial , a multidisciplinary program for the diagnosis and treatment of systemic hypertension, of the Federal university of Goias. Patients with arrythmia, diabetes, previous cardiovascular or cerebrovascular diseases, and end-stage diseases were excluded. Carotid Doppler test, measurements of peripheral and central blood pressure by applanation tonometry (Sphygmocor®) and oscillometry (Mobil-O-Graph®) were performed. The t-test was used for comparisons and the Pearson correlation test for correlations, considering a p<0.05 statistically significant. Results twenty patients (12 women) were evaluated, mean age 53.8 ± 14.3 years. Higher values of central pulse pressure (42.9±13.9 vs. 34.7±9.6, p=0.01) and pulse wave velocity (PWV) (9.0±1.9 vs. 7.9±1.5, p=0.01) were obtained by applanation tonometry compared with oscillometry. No difference between the methods was observed for the other measures. A significant correlation was found between carotid artery intima-media thickness (CA-IMT) and PWV (r=0.659; p=0.002) by the oscillometric test, but not with applanation tonometry. No correlation was found between central hemodynamic variables and the presence of carotid artery plaques. Conclusion PWV, estimated by oscillometry, was the only central hemodynamic parameter that correlated significantly with CA-IMT in pre-hypertensive and hypertensive patients at low cardiovascular risk. International Journal of Cardiovascular Sciences. 2020; [online].ahead print, PP.0-0

Resumo Fundamento: Os efeitos da caminhada de longa distância sobre o sistema cardiovascular são pouco estudados. Objetivos: O objetivo geral deste estudo foi verificar esses efeitos sobre o comportamento da função diastólica e dos biomarcadores cardíacos CK-MB (massa), troponina T e NT-proBNP em atletas amadores. Método: Este estudo longitudinal realizado em 2015 avaliou os participantes nas 5 etapas seguintes: A0 (basal) antes de iniciar o percurso, e as demais, A1, A2, A3 e A4 ao final de cada dia, totalizando 244,7 km. Em todas as etapas foram dosados os biomarcadores NT-proBNP, CK-MB (massa) e troponina T. Realizou-se ecocardiograma para análise das ondas E, A e E'. Adotado p < 0,05 como significativo. Resultados: Foram avaliados 25 participantes com média de idade de 46 ± 10,5 anos e índice de massa corporal de 20,2 ± 2,3 kg/m2. Encontrou-se aumentos dos valores de NT-proBNP de A0 para A1, A2, A3 e A4 (p < 0,001), CK-MB (massa) de A0 para A2 (p < 0,001) e da onda E' de A0 para A1, A2, A3 e A4 (p < 0,001). Foram identificadas correlações entre os seguintes: CK-MB (massa) e troponina T (A1: r = 0,524, p = 0,010; A4: r = 0,413, p = 0,044); CK-MB (massa) e NT-proBNP (A4: r = 0,539, p = 0,006); e E/A e E' (A0: r = 0,603, p < 0,001; A1: r = 0,639, p < 0,001; A4: r = 0,593, p = 0,002); e correlação negativa entre CK-MB (massa) com E/A (A1: r = −0,428, p = 0,041). Conclusão: Os efeitos da atividade física intensa, prolongada e intercalada foram verificados a partir das variações significativas no comportamento da CK-MB (massa), NT-proBNP e E'. Apesar das alterações encontradas, não houve critérios sugestivos de dano ao miocárdio.

Abstract Background: The effects of long-distance walking on the cardiovascular system have been little studied. Objectives: The general objective of this study was to verify these effects on the behavior of diastolic function and the cardiac biomarkers CK-MB (mass), troponin T, and NT-proBNP, in amateur athletes. Method: This longitudinal study, conducted in 2015, evaluated participants during the following 5 stages: E0 (baseline) before starting the trajectory and the others, E1, E2, E3, and E4, at the end of each day, totaling 244.7 km. At all stages, the biomarkers NT-proBNP, CK-MB (mass), and troponin T were measured. Echocardiogram was performed to analyze the E, A and E' waves. P < 0.05 was adopted as significant. Results: The study evaluated 25 participants, with an average age of 46 ± 10.5 years and body mass index of 20.2 ± 2.3 kg/m2. Increased values were found for NT-proBNP from E0 to E1, E2, E3, and E4 (p < 0.001), CK-MB (mass) from E0 to E2 (p < 0.001), and E' wave from E0 to E1, E2, E3, and E4 (p < 0.001). Positive correlations were identified between the following: CK-MB (mass) and troponin T (E1: r = 0.524, p = 0.010; E4: r = 0.413, p = 0.044); CK-MB (mass) and NT-proBNP (E4: r = 0.539, p = 0.006); and E/A and E' (E0: r = 0.603, p < 0.001; E1: r = 0.639, p < 0.001; E4: r = 0.593, p = 0.002). A negative correlation was found between CK-MB (mass) and E/A (E1: r = −0.428, p = 0.041). Conclusion: The effects of intense, prolonged, and interspersed physical activity were verified based on significant variations in the behavior of CK-MB (mass), NT-proBNP, and the E' wave. Notwithstanding the alterations found, there were no criteria suggestive of myocardial damage

Abstract Background Changes in arterial compliance are among the first changes detectable in hypertensive syndrome. Methods with good reproducibility as compared with the gold standard for identifying such changes are desirable in clinical practice. Objectives To compare central pressure measurements and arterial stiffness obtained by two non-invasive methods (tonometry and oscillometry). Methods This was a descriptive, cross-sectional study with a convenience sample of patients with borderline hypertension or stage 1 hypertension. Peripheral and central blood pressure measurements were obtained by tonometry (SphygmoCor®), considered the gold standard, and oscillometry (Mobil O´graph®). Comparisons of results were made by unpaired t-test, and p values < 0.05 were considered statistically significant. Results No difference was found in central pressure measurements obtained by SphygmoCor® (117 x 80.1 mmHg) compared with Mobil O’graph (112 x 81.4 mmHg). Mean augmentation index (AIx) was 26.1% and 21.3%, and mean pulse pressure (PP) amplification 10.7 mmHg and 10.0 mmHg by Sphygmocor® and Mobil O´graph®, respectively (p > 0.05). Mean pressure wave velocity (PWV), 8.4 m/s vs. 7.4 m/s (p = 0.013) and mean central pulse pressure, 37.7 mmmHg and 30.9 mmHg (p = 0.013) were significantly higher by SphygmoCor® than Mobil O´graph®. Conclusion Values of central systolic blood pressure, AIx and pulse pressure amplification obtained by oscillometry were not statistically different compared with tonometry; values of PWV and cPP, however, were underestimated by oscillometry. (Int J Cardiovasc Sci. 2020; 33(2):145-150)

Resumo Fundamento Os efeitos da redução na ingestão do sal sobre a pressão arterial (PA) casual de hipertensos já foram amplamente estudados, entretanto essa análise ainda é escassa no contexto da redução exclusiva do sal de adição na rigidez arterial e em indivíduos normotensos e pré-hipertensos. Objetivo Avaliar os efeitos da redução progressiva na ingestão do sal de adição (de 6 para 4 g/dia) sobre os valores da pressão periférica e central, a rigidez arterial em normotensos, pré-hipertensos e hipertensos. Métodos Ensaio clínico, simples cego com 13 semanas de seguimento. Foram avaliados normotensos (≤130/85 mmHg), pré-hipertensos (≥130 e <139/≥85 e <90 mmHg) e hipertensos estágio 1 (≥140 e <160/≥90 e <100 mmHg). Utilizou-se medida casual e monitorização residencial da PA com aparelho automático OMRON 705CP, medida central da PA com Sphygmocor®, dosagem do sódio urinário de 24h (colhido no intervalo entre cada visita) e mensuração de sal de adição. Foi adotado nível de significância p<0,05 para todas as análises. Resultados Foram avaliados 55 participantes (18 normotensos; 15 pré-hipertensos; 22 hipertensos) com mediana 48 anos (IQ:39-54). Os grupos foram semelhantes em relação a idade e sexo. Não houve diferença entre medidas de PA e excreção de sódio antes e depois da intervenção. Os parâmetros de rigidez arterial também não sofreram alterações significativas. Conclusão A redução gradativa da ingestão de sal de adição num seguimento de 13 semanas não foi capaz de reduzir de maneira significativa os valores periféricos e centrais da PA. (Arq Bras Cardiol. 2020; 114(3):554-561)

Abstract Background Although the effects of salt intake reduction on casual blood pressure have been extensively studied in hypertensive individuals, data on reductions of added salt on arterial stiffness in both normotensive and prehypertensive subjects are scarce. Objective To evaluate the effects of progressive reduction in added salt intake (from 6 grams to 4 grams per day) on peripheral and central blood pressure and arterial stiffness in normotensive, prehypertensive and hypertensive individuals. Methods This was a single-blinded clinical trial with 13 weeks of follow-up. Normotensive (≤ 130/85 mmHg), prehypertensive (≥ 130 e < 139/≥ 85 e < 90 mmHg) and stage 1 hypertensive individuals (< 139/≥ 85 and < 90 mmHg) were assessed. Casual blood pressure measurements and ambulatory blood pressure monitoring were performed using the automated OMRON 705CP device, and central blood pressure was measured using the Sphygmocor®. Twenty-four-hour urinary sodium excretion and the amounts of added salt consumed were measured. Statistically significance level was set at p < 0.05 for all analysis. Results A total of 55 participants (18 normotensive, 15 prehypertensive and 22 hypertensive), median age 48 years (IQR:39-54) were studied. The groups were not different in age or sex. No difference was observed in blood pressure or sodium excretion levels before and after the intervention. No significant changes in arterial stiffness parameters were observed. Conclusion The progressive reduction in added salt intake during a period of 13 weeks did not cause significant reductions in peripheral and central blood pressure. (Arq Bras Cardiol. 2020; 114(3):554-561)

RESUMO Indivíduos com o Transtorno do Espectro do Autismo (TEA) podem apresentar déficits em comportamentos sociais, como linguagem e interações interpessoais. Intervenções utilizando histórias sociais têm mostrado resultados promissores no ensino de comportamentos socialmente adequados e na redução de comportamentos socialmente inadequados em sala de aula, entre outros ambientes. Histórias sociais são personalizadas a partir do repertório comportamental de cada criança e apresentam as contingências de reforçamento envolvidas no comportamento desejado, no próprio ambiente em que o comportamento ocorre. O objetivo deste estudo foi verificar os efeitos da apresentação de histórias sociais na aprendizagem de comportamentos adequados e na redução de comportamentos inadequados de crianças com TEA em sala de aula. Os participantes foram dois meninos de seis e nove anos de idade, com diagnóstico de TEA, que apresentavam comportamentos inadequados diante de demanda social em ambiente escolar. Comportamentos-alvo para cada participante foram inseridos nas histórias sociais que mostravam as contingências do comportamento inadequado e da resposta alternativa adequada. Antes do início do período em que os comportamentos ocorriam com maior frequência, as histórias foram lidas para as crianças e as frequências dos comportamentos-alvo foram registradas durante a aula. Comportamentos adequados eram reforçados e os inadequados eram seguidos de procedimentos de correção. Os resultados indicaram aumento nos comportamentos adequados e diminuição nos inadequados para os dois participantes, e a diminuição da frequência de outros comportamentos inadequados não tratados diretamente na história social como efeito do engajamento em repertórios adequados de participação nas tarefas em sala de aula. Portanto, as histórias sociais parecem representar uma estratégia promissora na redução de comportamentos inadequados e aumento de adequados em sala de aula, com tempo curto de aplicação e baixo custo de construção dos materiais utilizados.

ABSTRACT Individuals with Autism Spectrum Disorder (ASD) may present deficits in social behaviors such as language and interpersonal interactions. Interventions that use social stories have shown promising results in teaching socially appropriate behaviors and in reducing socially inappropriate behaviors in the classroom, among other environments. Social stories are personalized from behavioral repertoire of each child and present the contingencies of reinforcement involved in the desired behavior, in the very environment in which the behavior occurs. The aim of this study was to verify the effects of social stories in the learning of appropriate behaviors and in the reduction of inappropriate behaviors of children with ASD in the classroom. The participants were two boys, 6 and 9 years old, diagnosed with ASD, who presented inadequate behaviors in response to social demands in school environment. Target behaviors for each participant were inserted into social stories that showed contingencies of inappropriate behavior and the appropriate alternative response. Before the beginning of the period in which the behaviors occurred more frequently, the stories were read to the children and the frequencies of target behaviors were recorded during class. Appropriate behaviors were encouraged and inappropriate ones were followed by correction procedures. Results indicated an increase in appropriate behaviors and a decrease in inappropriate behaviors for both participants, as well as a decrease in frequency of other inappropriate behaviors not directly addressed in the social stories as an effect of engagement in adequate repertoires of participation in classroom tasks. Therefore, social stories seem to represent a promising strategy in reducing inappropriate behaviors and increasing appropriate ones in the classroom, with short application time and low cost of construction of the materials used.

RESUMEN Los individuos con autismo pueden presentar déficit en comportamientos sociales, como lenguaje e interacciones interpersonales. Las intervenciones que utilizan historias sociales han apuntado resultados prometedores en la enseñanza de comportamientos socialmente adecuados y en la reducción de comportamientos socialmente inadecuados en clase, entre otros ambientes. Las historias sociales son personalizadas a partir del repertorio conductual de cada niño y presentan las contingencias de refuerzo involucradas en el comportamiento deseado, en el propio ambiente en que el comportamiento ocurre. El objetivo de este estudio fue verificar los efectos de la presentación de historias sociales en el aprendizaje de comportamientos adecuados y en la reducción de comportamientos inadecuados de niños con autismo en clase. Los participantes fueron dos niños de 6 y 9 años de edad, con diagnóstico de autismo, que presentaban comportamientos inadecuados ante demanda social en ambiente escolar. Los comportamientos objetivo para cada participante fueron insertados en las historias sociales que mostraban las contingencias del comportamiento inadecuado y de la respuesta alternativa adecuada. Antes del inicio del período en que los comportamientos ocurrían con más frecuencia, las historias fueron leídas para los niños y las frecuencias de los comportamientos objetivo se registraron durante la clase. Los comportamientos adecuados se reforzaban y los inadecuados se seguían de procedimientos de corrección. Los resultados indicaron aumento en los comportamientos adecuados y disminución en los inadecuados para los dos participantes, y también la disminución de la frecuencia de otros comportamientos inadecuados no tratados directamente en la historia social como efecto del compromiso en repertorios adecuados de participación en las tareas en el aula. Por lo tanto, las historias sociales parecen representar una estrategia prometedora en la reducción de comportamientos inadecuados y aumento de adecuados en el aula, con tiempo corto de aplicación y bajo costo de construcción de los materiales utilizados.

Resumo Buscou-se verificar os efeitos da formação de classes de estímulos equivalentes e de dois procedimentos de facilitação na emergência de respostas de analogia, comparando os resultados obtidos nos testes de analogia de acordo com o procedimento de facilitação e com o fornecimento de instrução. Participaram 30 universitários. Foram ensinadas as relações AB e AC entre figuras abstratas e testadas as relações de simetria, transitividade e analogia. Os participantes que não apresentaram essas relações foram expostos aos procedimentos de facilitação. Doze participantes responderam por analogia antes do procedimento de facilitação, cinco de oito (62%), após Facilitação 1 e três de dez (33%), após Facilitação 2. Dos sete participantes expostos à instrução, seis responderam por analogia. A formação das classes não foi suficiente para a emergência das respostas de analogia e alguns participantes podem ter respondido ao Teste de Analogia sob controle de apenas alguns aspectos dos pares de estímulos.

Abstract The goals were to verify the effects of the formation of equivalent stimulus classes and two facilitation procedures on the emergence of analogy responses and to compare the results obtained in the analogy tests according to the facilitation procedure and the provision of instruction. Participants were 30 undergraduate students. AB and AC relations were taught with abstract pictures, then symmetry, transitivity, and analogy relations were tested. Participants who did not show these relations were exposed to the facilitation procedures. Twelve participants responded by analogy before the facilitation procedure, five of eight (62%) after Facilitation 1 and three of ten (33%) after Facilitation 2. Of the seven participants exposed to the instruction, six responded by analogy. Class formation was not enough for the emergence of analogy responses, and some participants might have responded to the Analogy Test under the control of only some aspects of the stimulus pairs.

RESUMO Objetivo: Revisar as constatações científicas a respeito do método baby-led weaning (BLW) no âmbito da alimentação complementar. Fontes de dados: Buscas conduzidas na base de dados Sistema Online de Busca e Análise de Literatura Médica (MEDLINE)/PubMed em agosto de 2016 por dois examinadores independentes, sem delimitação de período. Foram utilizados os descritores: “baby-led weaning” OR “baby-led” OR “BLW”. Critérios de inclusão: estudos originais, disponibilizados em inglês, que abordaram o tema do método BLW. Critérios de exclusão: referências em outros idiomas, artigos de opinião e de revisão da literatura, editoriais e publicações que não discorreram sobre o assunto pretendido. Das 97 referências identificadas, 13 foram incluídas na síntese descritiva. Síntese dos dados: Os bebês adeptos ao BLW, quando comparados aos do grupo em conduta alimentar tradicional, foram menos propensos ao excesso de peso, menos exigentes em relação ao alimento e consumiam os mesmos alimentos da família. Os episódios de engasgo não diferiram entre os grupos. As mães que optaram pela implementação do BLW exibiram mais escolaridade, ocupavam um cargo gerencial no trabalho e apresentaram maior probabilidade de terem amamentado até o sexto mês. Foram mencionados preocupações com bagunça nas refeições, desperdício de comida e engasgo/asfixia, mas a maioria recomendava a adoção do método. Os profissionais da saúde demonstraram receio em indicá-lo. Conclusões: O BLW foi sugerido pelas mães que o seguiram com seus filhos, todavia relataram-se preocupações, que, somadas ao receio dos profissionais acerca da capacidade dos bebês de se autoalimentarem, refletem escassez de conhecimento sobre o método.

ABSTRACT Objective: To review the scientific findings on the baby-led weaning method (BLW) in the context of complementary feeding. Data sources: Two independent examiners searched the Medical Literature Analysis and Retrieval System Online (MEDLINE)/PubMed database in August 2016. No time-period was defined for the publication dates. The following descriptors were used: “baby-led weaning” OR “baby-led” OR “BLW”. Inclusion criteria were: original studies that were available in English, and which addressed the BLW method. Exclusion criteria were: references in other languages, opinion articles and literature reviews, editorials and publications that did not elaborate on the intended subject. Of the 97 references identified, 13 were included in the descriptive synthesis. Data synthesis: The BLW group of babies, when compared to the traditional eating group, were less prone to being overweight, less demanding of food, and ate the same foods as the family. The number of choking episodes did not differ between groups. Mothers who opted for the implementation of BLW had higher levels of schooling, held managerial positions at work, and were more likely to have breastfed until the sixth month of the child’s life. Concerns were raised about messes made during meals, wasting food, and choking, but most of the mothers recommended adopting the method. Health professionals were hesitant to indicate this method. Conclusions: BLW was recommended by mothers who followed the method with their own children. However, concerns have been reported, which, coupled with professionals’ fears about the inability of infants to self-feed, reflect a lack of knowledge about the method.

ABSTRACT In this work, two catalysts were produced to be used in hydrolysis of cellulose reactions to obtain glucose, a raw material used in the production of bioethanol. The heteropoly acid, H3PW12O40 (HPW), reported as strong and thermally stable acid, was supported on activated carbon (AC) in a ratio varying from 1:1 to 2:1 to produce the catalysts AC-HPW (1:1) and AC-HPW (2:1). The catalysts were tested in cellulose hydrolysis evaluating some reaction variables and the results show the remarkable dependence of reaction temperature, amount and acidity of the catalyst. The results indicate the advantage of supporting HPW on carbonaceous material for using as catalyst in hydrolysis of cellulose, showing better conversion rate into sugars comparing with unsupported HPW.

ABSTRACT Heteropoly salts containing different numbers of vanadium atoms (K4[PVW11O40] - KPWV1 and K6[PV3W9O40] - KPWV3) were synthesized from the heteropoly acid H3PW12O40 (HPW), and used as catalysts in hydrolysis of cellulose reactions in order to change the redox properties and verify whether the cluster of catalysts are involved in mechanism reaction. The hydrolysis reactions following a full 23 factorial design with the variables: mass ratio (catalyst/substrate), reaction time and temperature. The variables evaluated were significant at a 90% confidence level including second and third order interactions. According to the conducted experiments, the catalysts were all active in hydrolysis. The best results occurred when HPW was used suggesting that the redox properties did not have much influence in depolymerization of cellulose and the hydrolysis mechanism are assigned to acidic properties of the medium. The main products obtained from the reactions were glucose and HMF, which are products of great interest in the chemical industry.

RESUMO Carvões ativados em forma de briquetes foram preparados a partir do resíduo da madeira de candeia, gerado no processo de extração do óleo α-bisabolol. O material foi briquetado, carbonizado e ativado com CO2,variando-se a temperatura (700-900°C) e o tempo de ativação (1-3 horas). Para a caracterização dos carvões ativados foram realizadas análise elementar (CHN-O), análise dos grupos funcionais (titulação de Boehm), bur-off, área superficial BET estimada, índice de iodo, cálculo de área superficial com azul de metileno SAM, testes de adsorção com azul de metileno e fenol e índice de resistência mecânica. Os resultados mostraram que, com o aumento da temperatura e do tempo de ativação, ocorre aumento da área superficial, do volume de poros, da basicidade do carvão e da capacidade de adsorção de azul de metileno e de fenol.

ABSTRACT ThisActivated carbons briquette shaped were prepared from Candeia wood waste, generated in the extraction of α-bisabolol oil process. The material was briquetted, carbonized and activated with CO2, varying the temperature (700-900°C) and activation time (1-3 hours). The characterization of the activated carbons were performed by: elemental analysis (CHN-O), analysis of the functional groups (Boehm titration), Burn-off, estimated BET surface area, iodine index, calculation of surface area with methylene blue, adsorption tests with methylene blue (MB) and phenol and mechanical resistance (IRI).The results showed that increasing temperature and time of activation promoted an increased in the surface area, pore volume, basicity and adsorption capacity of AM and phenol.

ABSTRACT The aim of this study was to provide scientific knowledge to support the use of Vernonia condensata Baker, Asteraceae, beverages for their alleged hypocholesterolemic properties by testing their action as HMG-CoA reductase inhibitors and their capacity to lower dietary cholesterol permeation. Chlorogenic acid, and other caffeoylquinic acids derivatives were identified as the main components of these beverages by LC–MS/MS. No changes in the composition were notice after the in vitro gastrointestinal digestion and no toxicity against Caco-2 and HepG2 cell lines was detected. Cholesterol permeation through Caco-2 monolayers was reduced in 37% in the presence of these herbal teas, and the caffeoylquinic acids permeated the monolayers in 30–40% of their initial amount in 6 h. HMG-CoA reductase activity was reduced with these beverages, showing an IC50 of 217 µg ml−1. It was concluded that caffeoylquinic acids, the major components, justified 98% of the enzyme inhibition measured.